Soy-Based Formula? Neonatal Plant Estrogen Exposure Leads to Adult Inf

[nebula]

Soy-Based Formula? Neonatal Plant Estrogen Exposure Leads to Adult Infertility in Female Mice

ScienceDaily (May 2, 2012) — A paper published May 2 in Biology of Reproduction describes the effects of brief prenatal exposure to plant estrogens on the mouse oviduct, modeling the effects of soy-based baby formula on human infants. The results suggest that exposure to estrogenic chemicals in the womb or during childhood has the potential to affect a woman's fertility as an adult, possibly providing the mechanistic basis for some cases of unexplained female infertility.

<snip>

These findings raise the possibility that exposure to low levels of environmental or plant estrogens during sensitive developmental windows can alter the balance of the mucosal immune response in the uterus and oviduct. In the mouse, the window of development during which these changes can occur is found only in the neonatal period; in humans, development of the reproductive tract continues through the onset of puberty. Therefore, estrogenic chemical exposure to the female fetus, infant, child, and adolescent all have potential impacts on mucosal immunity in the reproductive tract and, therefore, on adult fertility. The authors present the view that limiting such exposures, including minimizing use of soy-based baby formula, is a step toward maintaining female reproductive health.

More here

[ayin jade]

And yet millions of asians eat tofu (soy bean curd) regularly, more so than soy based formula provides. I dont see asia suffering from inordinate number of infertility issues.

[The_Patriot21]

in fact, jade I see them having the exact opposite. I always wondered why they use mice to test stuff on, oh dear the mice have issues with this that must mean humans do to. . .how bout trying it on a chimp and seeing of it does anything, and thats not a 100% garentee its a good substitute, but its closer then a mouse.

[sPrevorb31]

And yet millions of asians eat tofu (soy bean curd) regularly, more so than soy based formula provides. I dont see asia suffering from inordinate number of infertility issues.

That is because they properly ferment the soy in Asia. Improperly fertilized soy contains phytoestrogens, which do prohibit fertility in women. In North America, soy is improperly processed or not processed at all, and this soy has been tested numerous times on mice, with the same results.

Feeding infants soy formula can disrupt their hormonal balance, and this doesn't show up until early teens - when the kids start sexually developing a few years earlier than they should. If they are still exposed to soy (as they will be if they eat much pre-packaged or fast food), they can become infertile as adults.

These are my references... I can pull up more.

http://www.optimumchoices.com/Soy.htm

http://www.skrewtips.com/2008/02/08/oh-soy-bad-how-we-are-mislead-about-the-benefits-of-soy/

http://www.naturalnews.com/025513.html

I researched soy for 2 months, and wrote about it in a blog post here.

[sPrevorb31]

in fact, jade I see them having the exact opposite. I always wondered why they use mice to test stuff on, oh dear the mice have issues with this that must mean humans do to. . .how bout trying it on a chimp and seeing of it does anything, and thats not a 100% garentee its a good substitute, but its closer then a mouse.

cause chimps are stronger than humans... don't want 'em to get out of control

[~candice~]

Well well well

I happen to have an opinion on this issue .

Blogs are often very poor sources of science, not referencing peer reviewed articles / clinical based medicine / randomised controlled trials to support their conclusions. It seems no matter what your opinion is, you can find a blog that will both support it and a blog to refute it. You wouldn't believe the number of blogs I read each day with awful statistics taken out of context that turn out to twist the evidence to say something it isn't. It's like reading a horror movie . For example, some women are actually taking soy supplements to improve their fertility. Yet in an alternative universe, other women are avoiding soy to improve their fertility.

My suggestion is to get onto a library website, or a journal website, and search for peer reviewed articles by qualified professionals. Then print them off, and take them to your doctor if you are concerned. As for the impact of soy on fertility, western fertility specialists are not that concerned.

[sPrevorb31]

Well well well

I happen to have an opinion on this issue .

Blogs are often very poor sources of science, not referencing peer reviewed articles / clinical based medicine / randomised controlled trials to support their conclusions. It seems no matter what your opinion is, you can find a blog that will both support it and a blog to refute it. You wouldn't believe the number of blogs I read each day with awful statistics taken out of context that turn out to twist the evidence to say something it isn't.

Wow candice. Thanks so much for encouraging me in my calling. It's very Christlike of you to do that in front of 150-minimum people.

[sPrevorb31]

Blogs are often very poor sources of science, not referencing peer reviewed articles / clinical based medicine / randomised controlled trials to support their conclusions. It seems no matter what your opinion is, you can find a blog that will both support it and a blog to refute it. You wouldn't believe the number of blogs I read each day with awful statistics taken out of context that turn out to twist the evidence to say something it isn't. Yet in an alternative universe, other women are avoiding soy to improve their fertility.

not referencing peer reviewed articles / clinical based medicine / randomised controlled trials

If you want references to scientific documents and research, I can provide that:

The Journal of the Society for Reproduction and Fertility

http://www.reproduction-online.org/content/143/3/247.full

The earliest evidence that naturally occurring phytoestrogens could cause reproductive disturbances in mammals was reported in 1946, indicating that sheep that grazed on red clover were infertile due to the estrogenic content in the clover (Bennetts et al. 1946, Morley et al. 1966). About 20 years later, a similar observation was made in cows that had fertility disturbances resulting from periods of stall-feeding on red clover (Kallela et al. 1984). Finally, a population of captive cheetahs exhibited infertility while eating soy-based diets (Setchell et al. 1987). In all three cases, fertility was restored when the phytoestrogen intake was reduced. Similarly, abnormalities in reproductive health due to high intake of soy products have been reported in several women (Amsterdam et al. 2005, Chandrareddy et al. 2008). These observations demonstrate that dietary phytoestrogens can have adverse effects on reproductive function in adults.

This is a study done by scientists on male mice, after which they examined the reproductive organs.

http://www.ipcbee.com/vol3/5-L014.pdf

In spite of the fact that soy bean have positive effects on the cure of diseases like osteoporosis ,vessel blockage, heart disease, blood-pressure, as well as having positive effects on the control of blood lipid level ,cure and control of the development of prostate, breast and clone cancers that has caused an increasing tendency in the world in using this grain in their daily diet, there are also some worries about negative effect of using soy in men diet, due to the bad effect of it on their reproductive system .

Another study.

http://tpx.sagepub.com/content/32/1/91.full.pdf

Regardless of how the effects are mediated, we conclude that isoflavone aglycones administered to mice in amounts chosen to approximate amounts ingested by some human beings who use soy-based dietary supplements have marked estrogenic effects on the reproductive system of male and female mice..

This study was done on women.

http://www.ajcn.org/content/81/1/189.full.pdf

The results of this trial do not support the hypothesis that soy protein containing isoflavones have beneficial effects on vascular function in older postmenopausal women. Whether certain subgroups of women (eg, equol producers) do benefit from the intervention remains to be elucidated.

Yet another study.

http://www.ncbi.nlm.nih.gov/pubmed/15668601

In conclusion, the findings in this randomized trial do not support the presence of a marked effect of soy protein substitution on quality of life (health status, life satisfaction, and depression) in elderly postmenopausal women.

Candice, I know my stuff - I've done the research, and there's plenty of evidence to prove the information that I've provided. Just because I write a blog doesn't mean that everything I write about is baloney - there are plenty of blogs by plenty of people who know what they are talking about.

[~candice~]

Wow candice. Thanks so much for encouraging me in my calling. It's very Christlike of you to do that in front of 150-minimum people.

Who said this is about YOU??? It has nothing to do with your calling, you didn't even say it was your calling. I didn't quote you, my comment was in general and you made the shoe fit.

My daughter is on a high soy diet and has been from birth because of all her allergies and I can tell you from experience that blogs are often dead wrong. She was on a soy based milk formula as an infant and the blog sourced information about it was often wrong, biased and inflamed. Her paed reassured us with literature that we were making a solid choice with soy amongst the alternatives. The HYPE about soy and fertility was discussed by my fertility specialist (who spent 8 years in college and another 4 years training as a specialist) who also showed me peer reviewed research to say that so long as you aren't in the ultra ultra extreme category, it really doesn't make an impact. You will also find that an estrogrenic effect is not always undesired in the world of fertility treatment and for women like me is extremely beneficial.

But if you are going to say this is your calling (blogging about health / food issues) then I have a few comments. Take it as you will.

Don't say things like this:

"It’s in everything. It’s everywhere. It’s not properly fermented. And it’s one of the things that is going to kill us."

(emphasis mine)

without immediately citing the scientific literature that supports your statement. In fact, just don't start a blog with that at all, period. I have to say that people having an opinion on the internet are a dime a dozen. You can find any opinion you like out there. If you want to be respected and not become a statistic, cite proper studies. Don't leap into emotive exaggerated statements with no qualification and no evidence. It immediately tells the reader that your style of writing is "evangelical", that you have a set idea about soy which is extreme and flavoured by feelings.

Don't say that the main source of your evidence is another blog. That makes your site a tertiary source of information at best.

You are dabbling with infant feeding (formula feeding) and fertility. I can tell you from experience as a mother and as an infertile woman that this is a hell fire topic. You MUST have a thick skin if you are going to make comments about the impact of people's choices on their child and on their own fertility.

Perhaps you will see when you get there, but people do not take it lightly to be told that what they chose to feed their child is having a negative impact on their child, especially when that information is delivered in a style that screams opinion and not science. I'm not trying to be mean, I am warning you - these are red hot topics amongst adults, and this coming from a teen blog is not well received. I am also concerned that you have the ability with statements like that to become nothing more than another voice of condemnation. I know you don't intend this, but in the blog/forum world there is an unending supply of people suggesting that mothers choices are wrong and are harming their babies. ESPECIALLY related to soy and to formula feeding. People call it poison... how would you like to be told you are feeding your child poison? Breast feeding failure is a common contribution to maternal feelings of depression, and so is having a child with different dietary needs. It makes the newborn period hell! When soy is the only option available (or any formula really, because you say it is in most of them...) and you have a screaming child, post-pregnancy hormones racing through your body, you don't want to be told you are feeding your precious newborn poison.

Fertility is about one of the most sensitive issues there is. Did you know there is a 26% rate of severe depression amongst women receiving fertility treatment? That women often have break downs because their life dream of having family is so severely disrupted by infertility? That women undergoing IVF in certain states MUST be screened by a psychologist and watched for signs of depression leading to suicide. I kid you not. So if you are going to play with such a sensitive topic, do it with scientific facts, don't add emotion, and ensure you are never yet another voice telling them what they did wrong (eating soy) to contribute to their condition. PLEASE!

If you are going to set yourself up as a person whose opinion should be respected, you should explain why. Especially when you indicate that your opinion should be respected above that of experts:

Soy contains trypsininhibitors which combat the absorption of protein. For this reason, if you are a vegetarian, you shouldn’t replace meat with unfermented soy, despite what the health experts say.

Finally, make sure your message is balanced. There is no agenda in writing scientific literature, at least there shouldn't be. So when you cite a paper, make sure when you write about it, you accurately reflect the conclusions the paper reached. Leave emotiveness out of it.

You said this in the above post:

In spite of the fact that soy bean have positive effects on the cure of diseases like osteoporosis ,vessel blockage, heart disease, blood-pressure, as well as having positive effects on the control of blood lipid level ,cure and control of the development of prostate, breast and clone cancers that has caused an increasing tendency in the world in using this grain in their daily diet, there are also some worries about negative effect of using soy in men diet, due to the bad effect of it on their reproductive system .

Reread the first (unbolded part). Now reread the first sentence of your blog that I copied above. Is soy going to kill us? Or is it more accurate to say there are both benefits (yes, the study you cited showed benefits!) and risks in taking soy, depending on your need?

Here is the summation of your blog:

So… lets sum that up in a more simple manner: soy makes it so your stomach can’t break down protein and minerals, contains the addictive MSG, causes thyroid tumours, possibly causes cancer, and contains poison.

Can you see the difference?

I'm really not trying to be nasty. But welcome to the world of scientific literature and blogs. Welcome to my world! I am a scientist and writing scientific literature is my bread and butter. Yes I am very passionate about it.

[sPrevorb31]

I apologize; I shouldn't have immediately taken it personal - you're right about me making the shoe fit.

Thank you for your advice - I understand what you're saying, and I'm going to edit that post.

Please forgive me for being snappish in my first reply.