I have heard several interpretations of Revelation 17 & 18 (as I'm sure everyone has). As far as the "religious system" is concerned, who will buy into it? The people who haven't accepted Jesus as Savior. With that in mind, I wouldn't want to have anything to do with it regardless of who is involved with or in leadership of it.
As far as the governmental system is concerned, it looks like (to me, anyway) that the anti-christ will have quite a bit of influence in it as well as the world economic system by extension. That would seem to leave a lot of room for individual nations to be involved in some way regardless of where the "capital" is.